It’s important not to simply be dismissive and dismiss their concerns out of hand. You have to be gentle. Caveat: they do not give it to all age groups. Administration of a clinical trial in a Xavier University Black Ivy League Shirt pediatric population (<18y) and even younger (<12y, toddlers, infants) is much, much more difficult to get regulatory approval. Source: microbiologist by training, clinical project manager for a large contract research organization (CRO) by employment. I believe they’d do a combined Phase2/3 trial for children – probably in the older age range of 10-18y. The big thing would be finding the minimum effective dose of the vaccine and establishing the efficacy level in kids. Truthfully, the urgency of need is lower in the pediatric population.
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I found this Lancet article about the CanSino vaccine – which I read about alongside the Oxford one in the NYT – in “phase 2” trials as well, but what does phase 2 mean? do the vaccines need wider testing before it goes out to the broader public? pls, explain to a dumb econ student. Exactly. They call it “Prime Boost” in Figure B here, and you can see the increased immune response compared to the Xavier University Black Ivy League Shirt single dose (Figure A). The number of people receiving it was smaller (n=10) and it wasn’t a blinded study, but it’s a marked improvement over two months.
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What they want to do is study this with as little variables as possible. Older people tend to take more medications and have more preexisting conditions. If grandpa goes into the trial and starts to develop hearing loss then is it because of the vaccine, his old age, his large Asprin regiment? Also, his heart condition is getting worse, is it because of the Xavier University Black Ivy League Shirt vaccine or his known heart disease? Lots of older people will result in lots of symptoms that may not be due to the vaccine and while you can try to statically rule them out it can become really hard when the list of symptoms is 70 different things. If you mostly test heather younger people you will still see those 70 different things but the incidence rate of them will be much smaller and easier to rule out.