They didn’t measure EEG in brain structures outside the cortex; the word “altogether” is highly misleading here. Almost certainly still plenty of neuronal activity happening, otherwise, Funny The Sheep Whisperer Vintage Shirt. The animals would have died. They also didn’t measure single neurons (EEG is a more collective measure), so we don’t know if activity stopped or merely desynchronized. What I find interesting here is a strong suggestion that subjective consciousness isn’t abolished despite a lack of cortical rhythms. Which in turn supports the idea that subcortical structures are more fundamentally important for consciousness itself.
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Cortex might be more important for creating its contents. The reported weights of the sheep used in this study would result in allometric dose scaling to a similar range as human doses. Funny The Sheep Whisperer Vintage Shirt. So 24mg/kg would be about twice the upper limit of anesthetic doses that would absolutely result in complete loss of consciousness. Edit: I should clarify, I’m a biologist myself. One way to interpret a study is to look at their design. It’s common to try and overload the system to see an effect and report on it. The authors are likely just publishing their results and the media or OP is sensationalizing it. If your experiment is built around a dose that a human being wouldn’t come close to surviving then its just a waste of time and money.
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This is common in so many drug studies. I’ve seen ones saying that caffeine + alcohol has the same effect on the brain as cocaine. Funny The Sheep Whisperer Vintage Shirt. It was the equivalent of injecting 12+ shots of high proof alcohol into your brain. Like a level that would be humanly unattainable. Dosage in “recreational” drug studies, I feel, are frequently misleading because to do this research, they apply an amount of drug that equates to the experimental equivalent of a sledgehammer, at biologically unattainable levels. I agree that it’s important to study a wide range of dosages, but there is little to no value in studying doses that are not possible/useful in humans. Outside of determining lethality.